LA JOLLA, Calif. – Artelo Biosciences, Inc. (NASDAQ: ARTL), a clinical stage biopharmaceutical company focused on the development of therapeutics that modulate endogenous signaling pathways, including the endocannabinoid system, today reported that its wholly owned Canadian subsidiary, Artelo Biosciences Corporation, and Dr. Steven Laviolette’s laboratory at the University of Western Ontario, have been awarded a Mitacs Accelerate grant. The grant is expected to fund 50% of expenses related to preclinical research investigating ART26.12 as a potential treatment for anxiety disorders.
ART26.12 is Artelo’s Fatty Acid Binding Protein 5 (FABP5) inhibitor program, which was licensed through an exclusive agreement and in collaboration with The Research Foundation of the State University of New York Stony Brook. In addition to anxiety disorders, the company plans to develop ART26.12 for the treatment of cancer, inflammation, and pain. Fatty Acid Binding Proteins have been identified as intracellular transporters for the endocannabinoid anandamide (AEA), a neurotransmitter produced in the brain. Inhibition of FABP5 has been shown to lead to higher levels of AEA and may have significant potential in treating anxiety. Artelo recently submitted a method of use patent with the U.S. Patent and Trademark Office covering the use of FABP5 inhibitors for the treatment of psychological disorders such as anxiety and post-traumatic stress disorder (PTSD).
Dr. Steven Laviolette, Professor in the Schulich School of Medicine, University of Western Ontario, London, Ontario, Canada and principal investigator for the study, stated, “Based upon the remarkable findings and well differentiated results of our prior work, we believe this translational research grant will help us more rapidly understand the therapeutic properties of ART26.12, including the potential of enhanced efficacy and reduced cognitive impact compared to current anxiolytics for the treatment of anxiety disorders.”
Gregory D. Gorgas, Artelo’s President and Chief Executive Officer added, “We appreciate the rigorous evaluation and resulting financial support of Mitacs. This grant further validates our drive to discover and develop new agents to more effectively and more safely fulfill unmet medical needs. We look forward to partnering with Dr. Laviolette to advance this exciting research.” The Mitacs funding is expected to support further pharmacology research, biomarker identification, neurotransmitter function characterization, and analysis of stress response following administration of ART26.12.
Mitacs is a not-for-profit organization that fosters growth and innovation in Canada by solving challenges with research solutions from academic institutions. Mitacs is funded by the Government of Canada and the Government of New Brunswick, along with the Government of Alberta, the Government of British Columbia, Research Manitoba, the Government of Newfoundland and Labrador, the Government of Nova Scotia, the Government of Ontario, Innovation PEI, the Government of Quebec, the Government of Saskatchewan, and the Government of Yukon. For information about Mitacs and its programs, see mitacs.ca/newsroom.
About Artelo Biosciences
Artelo Biosciences, Inc. is a San Diego-based biopharmaceutical company dedicated to the development and commercialization of proprietary therapeutics targeting endogenous signaling pathways including the endocannabinoid system. Artelo is rapidly advancing a portfolio of broadly applicable product candidates designed to address significant unmet needs in multiple diseases and conditions, including anorexia, cancer, PTSD, pain, and inflammation. Led by proven biopharmaceutical executives collaborating with highly respected researchers and technology experts, the company applies leading edge scientific, regulatory, and commercial discipline to develop high-impact therapies. More information is available at www.artelobio.com and Twitter: @ArteloBio